Type 2 diabetes (T2D) is a medical condition in which the body's blood glucose level is exceeded than the normal level. It is crucial to control the blood glucose level due to the complications it causes in the individual's health. This can be achieved by various antidiabetic medicines like sulfonylureas, meglitinides, metformin, thiazolidinediones, Dipeptidyl peptidase 4 (DPP-4) inhibitors, Glucagon-like peptide 1 (GLP-1) and SGLT-2 inhibitors. Due to the advantage and multifaceted approach of the SGLT-2 inhibitors, it is often suggested by the doctor. Today, we are going to discuss the SGLT-2 inhibitors in managing the blood sugar level in type 2 diabetes patients.
SGLT-2 inhibitors, also known as gliflozins, are a group of medicines that help treat type 2 diabetes in patients. They do this by preventing the reabsorption of glucose through the filter present in the kidney. This facilitates the excretion of excessive glucose through the urine. This mechanism of action is independent of insulin and primarily targets the kidneys, making SGLT-2 inhibitors a unique therapeutic option for T2DM.Medications like Forxiga 10mg Tablet, contain an active ingredient called dapagliflozin. This medicine can lower glucose reabsorption and the renal threshold for glucose. It mainly acts by removing excess sugar from the body via urine and lowering the sugar in the blood.
SGLT-2 can effectively reduce the blood glucose level and is also involved in various therapeutic activities, which are given below:
SGLT-2 helps to reduce the blood glucose level by increasing the glucose excretion through the urine. This can be effective in treating the patients with T2DM.
It is also associated with weight loss in individuals who have an increased risk of obesity-related diabetes by increasing the excretion of glucose (calorie loss) in urine. This reduced weight can help improve insulin sensitivity and the individual's overall metabolic health.
SGLT-2 inhibitors can help to reduce the blood pressure of the individuals which in turn aid in lowering the risk of cardiovascular events in diabetic patients. Thereby, it also helps to lower the risk of hospitalization for heart failure.
Antidiabetic medicines like SGLT are often involved in reducing the risk of kidney impairment in patients. Increased blood glucose levels can damage the blood vessels of the kidney and nephron (small unit of the kidney), which the SGLT-2 inhibitors can prevent.
It is estimated that the SGLT-2 inhibitor can help improve the liver function of individuals and aid in improving non-alcoholic fatty liver disease in patients.
SGLT-2 inhibitor can lead to the following side effects, which are given below:
Other serious side effects include genital infection, urinary tract infection, and diabetic ketoacidosis.
SGLT-2 is an effective tool in managing type-2 diabetes mellitus in patients. It is recommended to speak with your doctor about the benefits and adverse effects of the medication before using it. Inform your doctor of any previous medical issues before using the medicine. Your doctor can give an appropriate treatment for type 2 diabetes mellitus based on the health condition and the severity of the disease. SGLT-2 is a multifaceted medication used to treat diabetes and its related issues in patients. Further research and development can help reduce the medication’s adverse effects and improve the safety and efficacy of treating type-2 diabetes.